BASEL, Switzerland – 29th May 2018 Nouscom, an immuno-oncology company developing off-the-shelf and personalized neoantigen-based genetic cancer vaccines based on its clinically validated Exovax [...]
Empowering the immune response
Nouscom’s proprietary immunotherapy platforms utilize a portfolio of uniquely engineered viral vectors optimized for the efficient expression of long strings of tumor neoantigens and comprise a powerful toolkit for the induction of broad and potent anti-tumor T cell responses. The Company’s deep knowledge of vaccine manufacturing, and the platform’s capacity to reliably encode unprecedented numbers of neoantigens is combined with proprietary approaches to neoantigen prediction. Our mission is to generate safe, innovative, and potent next-generation neoantigen genetic vaccines and armored oncolytic viruses that selectively eliminate tumor cells. Our pre-clinical data indicate that our platform technologies are able to expand the applicability and efficacy of existing immunotherapies while delivering high levels of safety and tolerability.
Enhancing cancer-specific cellular immunity
With a proprietary portfolio of recombinant viral vectors, that redirect and potentiate anti-tumor cellular immunity
to focus on selected immunogenic tumor neoantigens. Our platform comprises two complementary technologies.
Exovax: Neoantigens genetic cancer vaccines
They encode an unprecedented number of tumor neoantigens for the induction and boosting of cancer-specific T cells. Nouscom proprietary viral vectors are engineered to encode multiple tumor neoantigens from a patient’s mutanome, expressed at high levels, irrespective of the order in which the neoantigens are assembled. Nouscom cancer vaccines include: a) an off-the-shelf vaccine encoding a large number of shared tumor neoantigens that are generated by frameshifts resulting from mismatch repair deficiency (dMMR)/microsatellite instability (MSI), and b) a personalized neoantigen vaccine tailored to individual patient mutanomes.
Endovax: Targeted oncolytic virus
It is delivered locally or systemically and armored with selected immune-modulators for use in solid tumors.
Our three lead programmes comprise: i) an off-the-shelf’ neoantigen cancer vaccine for mismatch repair deficient (dMMR)/microsatellite instability (MSI) tumors (NOUS-209); ii) a personalized genetic neoantigen cancer vaccine for solid tumors (NOUS-100-PV); and iii) a targeted oncolytic herpes virus (THV) for the treatment of solid tumors (NOUS-THV-001).
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