Next-generation off-the-shelf and precision viral vector neoantigen cancer immunotherapies
Our History
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Riccardo Cortese | MD, PhD Co-Founder
Riccardo founded the genetic vaccine company Okairos in 2007 and led the company through its successful acquisition by GSK in 2013. He sadly passed away in April 2017, but his intuitions, leadership and ability to recognize fields of research with untapped potential continue to drive and inspire our work each day.
Building upon our knowledge, manufacturing expertise and success in infectious disease vaccines based on viral vectors
Nouscom’s leadership and founding team are successful entrepreneurs, who have previously developed innovative candidate vaccines for a range of infectious diseases that include: Malaria (Ewer et al, 2013), Ebola (Stanley et al, 2014; Ewer et al, 2016), Respiratory Syncytial Virus (Taylor et al, 2015; Green et al, 2015), and Hepatitis-C virus (Swadling et al, 2014). The platform developed by Nouscom is based on proprietary recombinant Adenovirus isolated from non-human great apes (GAd) and Modified Vaccinia Virus Ankara (MVA). The use of viral vectors derived from primates has several advantages, in that they generate potent immune responses, and are much less susceptible to neutralization by pre-existing immunity in humans (Colloca et al, 2012). These vaccines have been evaluated in over 4,000 adult, newborn, and elderly healthy subjects, and shown to be safe, immunogenic and efficacious.
The team is now leveraging its experience and expertise in viral vectored vaccines design and development to advance a portfolio of novel, safe, and effective neoantigen immunotherapies to target human malignancies and expand the utility of existing immunotherapeutic agents, such as checkpoint inhibitors.
Successful past experiences are the building block of our new objectives.
Nouscom’s leadership and research team are successful entrepreneurs, who have previously developed innovative candidate vaccines for a range of infectious diseases that include: Malaria (Ewer et al, 2013), Ebola (Stanley et al, 2014; Ewer et al, 2016), Respiratory Syncytial Virus (Taylor et al, 2015; Green et al, 2015), and Hepatitis-C virus (Swadling et al, 2014). The platform technology, originally developed at Okairos, is based on recombinant Adenovirus isolated from non-human great apes (GAd) and Modified Vaccinia Virus Ankara (MVA). The use of viral vectors derived from primates has several advantages, in that they generate potent immune responses, and are much less susceptible to neutralization by pre-existing immunity in humans (Colloca et al, 2012). These vaccine therapies have been evaluated in over 4,000 adult, newborn, and elderly healthy subjects, as well as in patients with chronic infectious diseases, and shown to be safe and efficacious.
The team is now leveraging its experience and expertise in genetic vaccine development to develop a portfolio of novel, safe, and effective neoantigen and oncolytic-based vaccine therapies to target human malignancies and expand the utility of existing immunotherapeutic agents, such as checkpoint inhibitors.
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Riccardo Cortese | MD, PhD Co-Founder
Riccardo founded the genetic vaccine company Okairos in 2007 and led the company through its successful acquisition by GSK in 2013. He sadly passed away in April 2017, but his intuitions, leadership and ability to recognize fields of research with untapped potential continue to drive and inspire our work each day.
Management Team
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Marina Udier | PhD CHIEF EXECUTIVE OFFICER
Marina joined Nouscom in 2016 from Versant Ventures. Before Versant, she headed up the Global Neurodegeneration portfolio for Novartis Neuroscience and lead development of companion diagnostics for Novartis Oncology. She received her Ph.D. in Organic Chemistry from Yale University.
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Elisa Scarselli | MD Chief Scientific Officer and Co-Founder
Elisa was formerly a Research Scientist at IRBM/Merck, where she worked on immunological aspects of Hepatitis C infection and was subsequently appointed Group Leader in Oncology. She joined Okairos in 2010 as Clinical Director of the infectious disease vaccine programmes.
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Sven Gogov | MD Chief Medical Officer
Sven joined Nouscom as Vice President Clinical Development in October 2021. Prior to joining the company, Sven held Senior Clinical Development positions in oncology at Incyte, Novartis, OSI Pharmaceuticals and AstraZeneca. Previously he held an academic position at the University Health Network in Toronto, Canada
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Richard Davis | PHD Chief Operating Officer
Rick joined Nouscom in September 2020 from Johnson and Johnson Innovation where he was the Global Oncology Transaction Lead responsible for external collaborations and licensing of transformational preclinical assets. Previously he had responsibility for direct healthcare investments at Wellcome Trust, and has led business and corporate development for private and public biotechnology companies.
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Tiffany Muller Senior Vice President Finance
Tiffany has 15 years of experience in finance including investments, global treasury, and investor relations. Prior to joining Nouscom in 2019, she held leadership roles with a U.S. based Fortune 500 company where she oversaw complex finance facilities and debt issuances, managed large hedge portfolios, and cultivated investor relationships. Tiffany received her B.A. and M.A. in Mathematics.
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Loredana Siani | PHD Vice President Technical and CMC Development
Loredana was GMP head at Okairos/ Reithera since 2010 where she oversaw all the manufacturing campaigns for the production of APIs for both infectious diseases and advanced therapies. With extensive experience in developing technical operations conducted in compliance with Good Manufacturing Practice, she joined Nouscom in April 2020 as Technical Director.
Board of Directors
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Göran Ando | MD Chairman
Göran spent 35 years in the pharmaceutical industry as head of R&D and in general management. He is now board director and chairman of biotech companies in US, EU and Asia. He is a physician by training.
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Guido Magni | MD Board Director
Guido has been closely involved in multiple biotech investments. He was previously Managing Director of EuroVentures, a Versant incubator. He is a physician with a specialty in neuro-psychiatry, and the co-author of over 100 peer-reviewed papers.
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Joachim (JR) Rothe | PhD Board Director
Joachim joined LSP in 2002, and is currently a Managing Partner and co-owner of the firm. He has facilitated the growth and development of a large number of companies by leveraging his scientific and pharmaceutical expertise, and extensive global network.
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Genghis Lloyd-Harris | MD, PhD Board Director
Genghis’ current and past board positions include: Avillion, GenSight Biologics, HBI, Novexel, Solexa, Synosia and Wilson Therapeutics, and several others. He identifies and invests in new businesses, and supports portfolio companies.
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Scott Rocklage | PhD Board Director
Scott joined 5AM Ventures in 2003 as a Venture Partner and became a Managing Partner in 2004. He has over three decades of healthcare management experience and has entered multiple drug candidates into clinical trials.
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Marina Udier | PhD Board Director
Marina joined Nouscom in 2016 from Versant Ventures. Before Versant, she headed up the Global Neurodegeneration portfolio for Novartis Neuroscience and lead development of companion diagnostics for Novartis Oncology. She received her Ph.D. in Organic Chemistry from Yale University.
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Jean-Paul Prieels | PhD Board Director
Jean-Paul is a Director of Vaximm AG and a member on Curevac independent Advisory Board. He was instrumental in developing several licensed vaccines and served as the Head of Research at GSK Vaccines.
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John F. McDonald | JD, MBA Board Director
John has over 25 years of business development experience with some of the industry’s premier companies, including Genentech, Genzyme, Millennium Pharmaceuticals, MPM Capital, Biogen and currently Novo Nordisk.
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Vincent Brichard | MD, PhD, MBA Observer
Vincent has more than 25 years of oncology and immunology experience. His experience encompasses a broad and integrated approach to immunotherapy – from bench discovery through to regulatory and commercial activities.
Key Advisors
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Alfredo Nicosia | PhD Co-founder
Alfredo was previously Chief Executive Officer of Nouscom and co-founders and Chief Scientific Officer of Okairos. He led the preclinical and clinical development of several vaccines and monoclonal antibodies against various infectious diseases and human cancers.
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Stefano Colloca | MD Co-founder
Stefano co-founded Okairos, where he was Senior Director for Vector Development. He has overseen and directed GMP manufacturing campaigns for numerous clinical trials.
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Antonella Folgori | PhD Co-founder
Antonella was a co-founder of Okairos and Director of Immunology. She is a named inventor on several patents, and contributed to the preclinical and clinical validation of multiple infectious disease vaccine programmes.
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Cinzia Traboni | PhD CO-FOUNDER AND R&D GMO MANAGER
Cinzia Traboni is a Nouscom co-founder and R&D GMO Manager. Previously she was Head of Regulatory Affairs and she was responsible for the RA activities supporting clinical trials in thefield of cancer immunotherapy, in US and in EU. She was also Regulatory Affairs Head of Okairos, where she coordinated the company regulation submissions for multiple clinical trials in the field of vaccines to infectious diseases in EU.