Nouscom Poster presentation at CIMT 2022

Nouscom Poster presentation at CIMT 2022, reporting on the generation of a Modified Vaccinia Ankara (MVA) virus encoding IL-12 as a novel approach of “Vector Aided Microenvironment Programing: VAMP” to turn immunologically cold tumors hot. Intratumoral injection of VAMP-IL-12 is highly effective in multiple preclinical tumor models resistant to checkpoint inhibitors (CPI), as stand-alone treatment and in combination with anti-PD1, supporting the use of VAMP-IL-12 as a novel strategy to overcome TME mediated resistance to immunotherapy.

• De Lucia et al.,  CIMT 2022 Modified vaccinia virus Ankara expressing IL-12 overcomes tumor resistance through the reprogramming of the tumor microenvironment